Designing of a Sensor for Monitoring Drug in Spiked Serum Samples – Preventing Drug Toxicity

Abstract

This research introduces a MIP based electrochemical sensor for theophylline detection, utilizing a pencil graphite electrode (PGE) modified with ZnO Nano Flakes, reduced graphene oxide (rGO), and pyrrole which undergoes in-Situ chemical reaction to form polymerized layer. Molecular imprinting provided selective binding sites for theophylline, enabling high specificity. The sensor achieved a low detection limit of 0.94nM, with strong selectivity against similar compounds and excellent reusability as MIP based can be used repeatedly. Its fast response and simple fabrication make it ideal for real-time, point-of-care drug monitoring