Department of Physics

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    Synthesis of rGO/Fe3O4/CS Nanobiocomposite to Fabricate Screen Printed Electrode for the Detection of Norepinephrine (NE)
    (Library Information Services, COMSATS University Islamabad, Lahore Campus, 2024) Junaid Hassan; CIIT/FA22-RPH-006/LHR; Dr. Akbar Ali; LHR TP 9433
    This research requires synthesizing of rGO/Fe3O4/CS nanobiocomposite to fabricate Screen Printed Electrodes (SPEs), which will be used to detect norepinephrine (NE). They are Fe3O4 nanoparticles that are of magnetic nature, chitosan which are biocompatible and rGO which has appreciable electrical conductivity were combined in an efficient and environmentally friendly manner by co-precipitation method to produce the nanobiocomposite. Characterization of rGO/Fe3O4/CS was done using FTIR, SEM, XRD, Raman, and UV-Vis spectroscopy through which the structure and morphology of the synthesized material were explained. Experiments done using EIS and cyclic voltammetry indicate that the modified SPEs were electrochemically more sensitive to NE analyze than the bare SPEs. Thus, application of the rGO/Fe3O4 and CS electrodes led to the decrease in the effective limit, increasing the sensitivity and expanding the linear range of detection. The utilization of the nanocomposite components might be because of the synergistic impact in regard to electron transfer rates and a high NE adsorption surface. This work bearing futuristic facts in neurochemical surveillance and medical diagnosing establishes the possibility of employing SPEs incubated with rGO/Fe3O4/CS nanobiocomposite as a reliable and effective system for neurotransmitter detection.
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    Synthesis of rGO/Co3O4 Nanobiocomposite for the Modification of Screen Printed Electrode to Fabricate a Biosensor for the Detection of Neurological Disorders
    (Library Information Services, COMSATS University Islamabad, Lahore Campus, 2022) Raheela Mansab; CIIT/SP21-RPH-026/LHR; Dr. Akbar Ali; LHR TP 8240
    Due to rapidly increasing neurological disorder, there is a continuous need for the development of rapid and accurate diagnosis methods. An electrochemical biosensor fabrication is involved in this research project which is done by the modification of screen printed electrode with rGO/Co3O4/Chitosan nanobiocomposite. This biosensor was used for the detection of Norepinephrine neurotransmitter whose abnormal level leads to depression that is a major risk factor for neurological disorders. Chitosan based nanocomposites are widely used in the fabrication of biosensors all thanks to its biocompatible, biodegradeable and non toxic properties. Graphene Oxide was prepared by modified Hummers method, rGO/Co3O4 nanocomposite was prepared by one step hydrothermal method, and rGO/Co3O4/Chitosan nanobiocomposite was prepared by solution mixing technique. At the end to fabricate a biosensor, SPE was modified with prepared nanobiocomposite by drop casting method. The as prepared material was characterized by Raman spectroscopy, FTIR, XRD and SEM. The electrochemical response was checked by cyclic voltammetry and electrochemical impedance spectroscopy.
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    Synthesis of rGO/NiO/CS Nano-biocomposite to Fabricate Screen Printed Electrode for the Detection of Neurological disorder
    (Library Information Services, COMSATS University Islamabad, Lahore Campus, 2025) Muhammad Saalam; CIIT/FA23-RPH-028/LHR; Dr. Akbar Ali; LHR TP 9856
    Due to rapidly increasing neurological disorder, the reisa continuous need for the development of rapid and accurate diagnosis methods. An electrochemical biosensor fabrication is involved in this research project which is done by the modification of screen print edelectrode with rGO/NiO/Chitosan nanobiocomposite. This biosensor was used for the detection of Neurological disorder who’s abnormal levelleads to depression that is a major risk factor for neurological disorders. Chitosan based nano composites are widely used in the fabrication of screen-printed aelectrodes thanks to its biocompatible, biodegradeable andnontoxic properties. Graphene Oxide was prepared by modified Hummer’s method, rGO/NiO/CS nanocomposite was prepared by one step hydrothermal method, and rGO/NiO/Chitosan nanobiocomposite was prepared by solution mixing technique. At the end to fabricate a biosensor, SPE was modified with prepared nanobiocomposite by drop casting method. The prepared material was characterized by Raman spectroscopy, FTIR, XRD and SEM. The electrochemical response was checked by cyclic voltammetry spectroscopy.