Department of Physics

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Author: search.filters.author.Dr. Akbar AliSubject: search.filters.subject.fa22

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    Synthesis of rGO/Fe3O4/CS Nanobiocomposite to Fabricate Screen Printed Electrode for the Detection of Norepinephrine (NE)
    (Library Information Services, COMSATS University Islamabad, Lahore Campus, 2024) Junaid Hassan; CIIT/FA22-RPH-006/LHR; Dr. Akbar Ali; LHR TP 9433
    This research requires synthesizing of rGO/Fe3O4/CS nanobiocomposite to fabricate Screen Printed Electrodes (SPEs), which will be used to detect norepinephrine (NE). They are Fe3O4 nanoparticles that are of magnetic nature, chitosan which are biocompatible and rGO which has appreciable electrical conductivity were combined in an efficient and environmentally friendly manner by co-precipitation method to produce the nanobiocomposite. Characterization of rGO/Fe3O4/CS was done using FTIR, SEM, XRD, Raman, and UV-Vis spectroscopy through which the structure and morphology of the synthesized material were explained. Experiments done using EIS and cyclic voltammetry indicate that the modified SPEs were electrochemically more sensitive to NE analyze than the bare SPEs. Thus, application of the rGO/Fe3O4 and CS electrodes led to the decrease in the effective limit, increasing the sensitivity and expanding the linear range of detection. The utilization of the nanocomposite components might be because of the synergistic impact in regard to electron transfer rates and a high NE adsorption surface. This work bearing futuristic facts in neurochemical surveillance and medical diagnosing establishes the possibility of employing SPEs incubated with rGO/Fe3O4/CS nanobiocomposite as a reliable and effective system for neurotransmitter detection.
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    Fabrication and Characterization of Co3O4-Fe2O3-Chitosan Ternary Nanobiocomposite Electrode for Neurotransmitters Detection Applications
    (Library Information Services, COMSATS University Islamabad, Lahore Campus, 2024) Talha Tariq; CIIT/FA22-RPH-008/LHR; Dr. Akbar Ali; LHR TP 9434
    This study focuses on the fabrication and characterization of a Co3O4-Fe2O3-Chitosan ternary nanobiocomposite electrode for detecting neurotransmitters, with a specific emphasis on Norepinephrine. The combination of these materials creates a unique electrochemical platform that offers enhanced sensitivity and selectivity for the detection of neurotransmitters, which are crucial biomarkers in diagnosing neurological diseases. The research involved synthesizing and analyzing Co3O4 nanoparticles, Co3O4-Fe2O3 (3:1) nanocomposites, Co3O4-Fe2O3-CS (3:1:2%) nanobiocomposites, and Co3O4-Fe2O3-CS (3:1:1%) nanobiocomposites. The nanobiocomposites, designed for neurotransmitter detection, specifically Norepinephrine, were thoroughly characterized and evaluated using a range of analytical techniques. These included X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, Ultraviolet-Visible Spectroscopy (UV), Cyclic Voltammetry (CV), Electrochemical Impedance Spectroscopy (EIS), and Differential Pulse Voltammetry (DPV). The analyses provided valuable insights into the structural, morphological, and electrochemical properties of the fabricated nanobiocomposite electrode. These findings demonstrate its potential for accurately detecting Norepinephrine in biological samples with high sensitivity and selectivity.