Abstract:
Covalent organic frameworks, often known as COFs, are permanent porosity and highly
ordered crystalline porous organic materials. COFs can be synthetically controlled,
structurally predesigned, and functionally managed, in contrast to other materials. In order
to create complicated structures and customized functional development, COFs provide an
appropriate molecular platform. They are perfect for drug delivery because of their greater
surface area, biodegradability, and crystallinity. In this study, a simple and adaptable
synthesis technique was develop to produce COF LZU1 and utilize it as a model medicine
to deliver 5-fluorouracil (5FU), a popular anticancer drug. During the synthesis of COFs,
the choice of building units and suitable conditions are the two most important factors. Here,
we successfully create imine-linked COF-LZU1 at room temperature through the
condensation process of 1,3,5 triformyl benzene with p-Phenylenediamine. For biomedical
applications, such as targeted drug delivery, controlled drug release, and biocompatibility,
ZnO is added to LZU1 to improve its characteristics. By using FTIR and XRD, the synthesis
of Zn@COF-LZU1 and COF-LZU1 was verified. In FTIR spectra C=N appears at 1617 cm-
1 that confirms the condensation reaction between two selected monomers. The prominent
diffraction peak at 2θ at 4.78o in XRD demonstrates that COF-LZU1 is crystalline. The main
objective was to create and enhance a 5-fluorouracil system using the Box-Behnken design
(BBD). Drug concentration, pH, and time are all set in accordance with the Box-Behnken
design for the experiment. In order to determine the interaction between the independent and
dependent variables, Design-Expert's contour, mathematical calculations, response surfaces
designs were used
