Synthesis and Characterization of COFs Composite for Cancer Drug Delivery

Abstract

Covalent organic frameworks, often known as COFs, are permanent porosity and highly ordered crystalline porous organic materials. COFs can be synthetically controlled, structurally predesigned, and functionally managed, in contrast to other materials. In order to create complicated structures and customized functional development, COFs provide an appropriate molecular platform. They are perfect for drug delivery because of their greater surface area, biodegradability, and crystallinity. In this study, a simple and adaptable synthesis technique was develop to produce COF LZU1 and utilize it as a model medicine to deliver 5-fluorouracil (5FU), a popular anticancer drug. During the synthesis of COFs, the choice of building units and suitable conditions are the two most important factors. Here, we successfully create imine-linked COF-LZU1 at room temperature through the condensation process of 1,3,5 triformyl benzene with p-Phenylenediamine. For biomedical applications, such as targeted drug delivery, controlled drug release, and biocompatibility, ZnO is added to LZU1 to improve its characteristics. By using FTIR and XRD, the synthesis of Zn@COF-LZU1 and COF-LZU1 was verified. In FTIR spectra C=N appears at 1617 cm- 1 that confirms the condensation reaction between two selected monomers. The prominent diffraction peak at 2θ at 4.78o in XRD demonstrates that COF-LZU1 is crystalline. The main objective was to create and enhance a 5-fluorouracil system using the Box-Behnken design (BBD). Drug concentration, pH, and time are all set in accordance with the Box-Behnken design for the experiment. In order to determine the interaction between the independent and dependent variables, Design-Expert's contour, mathematical calculations, response surfaces designs were used