Abstract:
Existing wound closure systems, e.g. sutures and staples contain many disadvantages i.e.,
discomfort to patient, allergenic effect, complex procedures and high cost. UV curable
adhesives are more advantageous in their applications to damaged tissues as compared to
other conventionally available tissue sealants. The UV curable systems are mechanically
stable, biocompatible, cause no toxicity, and most importantly have fast-curing rates, and
better cohesive and adhesive strengths. Utilization of polymeric chitosan is the best
strategy to overcome undesired problems in wound management. The sealing
characteristics of polymeric adhesive chitosan has been studied. Hydrocaffeic acid
modified chitosan (Ch-HCA) was prepared to enhance the mucadhesion strength and
stability. Chitosan functionalized with photosensitive 4-azidobenzoic acid (AzCh) readily
cross linked under the UV irradiations. Ultraviolet (UV) irradiation induces molecular
changes in tissue biology by photochemical interactions. This approach is safe and quick
in which wound could be efficiently sealed via photochemical reactions. AzCh-HCA thin
films could behave as a strong tissue-adhesive and induce effective wound healing.
