Utilization of Ultraviolet radiations for the closure of wounds

Abstract

Existing wound closure systems, e.g. sutures and staples contain many disadvantages i.e., discomfort to patient, allergenic effect, complex procedures and high cost. UV curable adhesives are more advantageous in their applications to damaged tissues as compared to other conventionally available tissue sealants. The UV curable systems are mechanically stable, biocompatible, cause no toxicity, and most importantly have fast-curing rates, and better cohesive and adhesive strengths. Utilization of polymeric chitosan is the best strategy to overcome undesired problems in wound management. The sealing characteristics of polymeric adhesive chitosan has been studied. Hydrocaffeic acid modified chitosan (Ch-HCA) was prepared to enhance the mucadhesion strength and stability. Chitosan functionalized with photosensitive 4-azidobenzoic acid (AzCh) readily cross linked under the UV irradiations. Ultraviolet (UV) irradiation induces molecular changes in tissue biology by photochemical interactions. This approach is safe and quick in which wound could be efficiently sealed via photochemical reactions. AzCh-HCA thin films could behave as a strong tissue-adhesive and induce effective wound healing.