Abstract:
Magnetic materials such as ferrites are substances that come crossways in powder
form and ceramic based material with ferromagnetic properties attained via iron
oxides (IO), their foremost components are Fe2O3 and Fe3O4 and further can be doped
by transition metals and metal oxide nanomaterials . The ferrites and metallic doped
ferrites are mentioned as magnetic materials and have various applications such as
photocatalysis, drug carrier in cancer treatment, hydrogen production and electronic
expedients. Among the various ferrites, manganese ferrite (MnFe2O4) has superior
and distinct magnetic, physical and chemical properties leading to numerous
biomedical applications. The statistics showed that antibacterial toxicity mostly is
influenced by particle size and concentration. The magnetic materials were shown
enough potential in antimicrobial activity against various microorganisms and based
on these properties that materials can further be used in numerous biomedical
applications. Therefore, in present research work, efforts will be carried out by
making the nanocomposite of silver doped manganese ferrite NPs to enhancement in
the bactericidal action. Silver based nanomaterial and its composites for example AgMnFe2O4 in a biological point of view require an detailed origination with outstanding
antibacterial properties with decline toxicity quality and morphological evaluations of
these materials is as yet appealing test for future interest. Here, in this experimental
work, we have synthesized and characterized Ag-MnFe2O4 by X-ray diffraction
(XRD), Uv-Vis spectroscopy, Field emission scanning electron microscopy FESEM,
for morphological and essential study. Toxicity of Ag-MnFe2O4 nanocomposite was
surveyed by means of methyl-thiazole-tetrazolium (MTT) measure, and
morphological changes realize Ag-MnFe2O4 in Escherichia coli (E.coli) investigated
by confocal checking electron microscopy with magnification of ×40. The toxicity of
Ag-MnFe2O4 nanoparticle was assessed by estimating the degree of misfortune in cell
viability (%) in dose dependent which caused the cell destruction in apoptotic/necrotic
way. The reason of bacterial death due oxidative pressure trigger by reactive oxygen
species (ROS) expressed potential role of Ag-MnFe2O4 for enhancement of
antimicrobial activity of E coli as an effective antibacterial specialist.
