Antibacterial Effect of Gold doped ZrO2 Nanoparticles for Wound Healing Application

Abstract

Metallic Np`s are well known for biological applications as well as antimicrobial activity and wound dressing materials. As an alternative to antibiotics, nanoparticles (NPs) are increasingly being employed to target bacteria. Antibacterial coatings for implantable devices and promote wound healing and medicinal materials to prevent infection, bacterial detection systems to generate microbial diagnostics, antibiotic delivery systems to treat disease, and antibacterial vaccines to control bacterial infections are all examples of NP applications. Gold doped zirconium oxide (Au-ZrO2) was used in this study. For antibacterial properties, gold doped ZrO2 NPs were produced using a co-precipitation technique. The antibacterial test was carried out using the well diffusion method. The zone of inhibition against E. coli and S.aureus was measured. Higher gold doping concentrations result in a broader inhibition zone against gram positive and gram-negative microorganisms. Fourier Infrared Transform Spectroscopy (FTIR), X-Ray diffraction (XRD), Raman spectroscopy, and Scanning Electron Microscopy were used to analysis the produced nanoparticles (SEM). The existence of the ZrO2 functional group is explained by FTIR analysis and crystalline structure is determined by XRD. Raman spectra also confirm the optical and vibrational phonons and magnons present in ZrO2. SEM corroborated the morphology of nanoparticles.