Sensing Platform based on Metal Organic Framework for the Quantitative Determination of Antibiotic Remains in Animal Derived Food

Abstract

In this pioneering research work, we have successfully synthesized a highly advanced Copper Gallic Acid-L-Arginine Metal-Organic Framework (Cu-Gallic Acid-L-Arginine MOF) and ingeniously engineered it into an extraordinary electrochemical sensor, enabling the unparalleled sensitivity in the detection of chloramphenicol (CAP). To validate the successful formation of the Cu-Gallic Acid-L-Arginine MOF, a comprehensive array of cutting-edge characterization techniques including Scanning Electron Microscopy (SEM), UV-Vis Spectroscopy, Fourier-Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), and Zeta potential analysis were meticulously employed. To evaluate the exceptional electrochemical properties of the Cu-MOF-based sensor, Electrochemical Impedance Spectroscopy (EIS) and Cyclic voltammetry (CV) were utilized, providing deep insights into its performance. Furthermore, the Cu-MOF-modified Pencil Graphite Electrode (PGE) demonstrated excellent detection proficiency in the presence of chloramphenicol. The performance of the developed sensor was truly remarkable, showcasing an extensive linear detection range from 1nM to 1000nM, along with an astonishingly low detection limit of 0.36nM (S/N = 3). Moreover, this highly promising sensor showcased exceptional sensitivity, robust stability, impressive repeatability, and a commendable recovery rate for the electrochemical detection of CAP in real samples. These ground-breaking findings elevate the Cu-Gallic Acid-L-Arginine MOF-based sensor to an unprecedented level, positioning it as a leading-edge technology for CAP detection, and underscoring its immense potential in diverse applications.