Bilayer Electrospun Membrane Modification with Phytochemicals for Wound Healing / Scar Removal

Abstract

The main aim of this work was to synthesize bilayer polymeric membranes through electrospinning and then modify the surface of those membranes with phytochemicals by dip coating. These modified membranes are prospective candidates for wound healing and scar removal. Electrospinning is relatively a new technique to produce nano and micro fibrous membranes having nano and microporous morphology for various biomedical applications. Phytochemicals such as Licorice and Bearberry extracts have been used for centuries in Ayurveda and traditional medicine throughout the world, including Persia, China, India and the Pakistan. These extracts have been found effective in the treatment of wounds, hyperpigmentation, melanin reduction, skin aging, freckles and scars for hundreds of years. Many phytochemicals such as alkaloids, flavonoids, tannins, terpenes, arbutin, glyrrhizic acid, volatile oils and organic acids have been found in the chemical composition of the licorice and bearberry extracts. These compounds possess antibacterial, antioxidant, anti-inflammatory, antimicrobial, and in anticancer activities