2 Deoxy-D-ribose Releasing Sodium Alginate Based Hydrogels for Burn Wounds and Diabetic Ulcers

Abstract

2 Deoxy-D-Ribose has important biomedical applications due to its ability to stimulate angiogenesis, particularly in chronic and diabetic wound healing. The goal of this study was to see if manufactured tube hydrogel accelerates wound healing by stimulating angiogenesis in rats. 2 Deoxy-D-Ribose (2dDR), a small sugar, was loaded into sodium-alginate to produce a tube hydrogel. FTIR analysis confirmed the presence of sodium-alginate functional groups in freeze dried membranes. Drug release studied indicated that that approximately 98% of 2dDR was released between 1-7 days, that is beneficial for angiogenesis and wound healing. Antibacterial test revealed indicate that the sugar could not be metabolized by strains of E. Coli and Staphylococcus aureus. The rat models treated with alginate blank-Gel significantly promote wound healing and the 5% of 2 Deoxy-D-Ribose further significantly showed a rapid full thickness wound healing up to day 14 in contrast to untreated rat. Hair regeneration in rat model showed extensive hair follicle regrowth in 5% of 2 Deoxy-D-Ribose treated portion as compared to other groups. All these experiments confirm that these 2 Deoxy-D-Ribose (2dDR) tube hydrogel is suitable to use for stimulating angiogenesis and maintaining moist environment to accelerate wound healing applications