Antibacterial dual cross-linked hydrogels for Periodontal Regeneration

Abstract

Periodontitis is one of the most common gum diseases caused by bacterial infection. It affects teeth's surrounding bone and tissues. It is important to treat the disease promptly as it not only results in tooth loss but also affects the general health of the patient. It is extremely common in young individuals with occurrence rates of approximately 50% across the world. Different graft materials are used to treat periodontal defects, but unpredictable clinical outcomes of existing solutions encourage developing novel materials with enhanced functionality. This study aimed to formulate oval proteins, hydroxyapatite (HA) and PVA based anti-bacterial dual cross-linked hydrogels for periodontal regeneration. Potential non-toxic and biodegradable oxidized alginate, borax and divalent ionic (Cu+2, Zn+2, Ca+2) solutions were used as cross linking agents. Oval proteins act as efficient gelling agent and can mimic the ECM microenvironment. Hydrophilicity, potential bio-degradation, outstanding cytocompatibility, less cytotoxicity, surface alignment features, and self-healing are some of distinctive properties of prepared hydrogels. Hydroxyapatite (HA) is a bio-ceramic and used as bone regeneration material.