Self-healing Hydrogels as an Efficient Local Drug Delivery System to Treat Periodontitis

Abstract

Periodontitis is an infection-related, inflammatory condition of the gums. The periodontal tissue is harmed. It can result in tooth loss and a host of other health issues if left untreated. A system that is effective against bacteria and has the ability to regenerate tissue is needed for treatment. Hydrogels that are both affordable and antimicrobial have been created in this study as an efficient local drug delivery system. The synthesis of hydrogels includes polymers polyvinyl alcohol, gelatin, hydroxyapatite, glutaraldehyde and borax as a crosslinkers. The hydrogel is self-healing and has mechanical strength. Metronidazole loaded on it which very effective antibiotic against gram negative strains of bacteria that cause periodontitis. Hydroxyapatite modified with arginine which enhance the wound healing capability of hydrogels. Different characterizations have done for hydrogels FTIR shows dual crosslinking in hydrogels. Drug release study shows the significant release of drug which is helpful in first 24h of healing. Water contact angle measurement shows that the hydrogels are hydrophilic which is helpful in the attachment with cells. Degradation studies confirm the biodegradability of hydrogel. The hydrogels are effective against both E. coli and S. Aureus strains of bacteria. All the characterizations and studies lead to healthy use of hydrogels without any side effect in the treatment of hydrogels.