Department of Chemistry
Permanent URI for this communityhttps://repository.cuilahore.edu.pk/handle/123456789/14
Browse
2 results
Search Results
Item Synthesis and Characterization of TiO2/Cellulose@ZIF-8 for the Application of Drug Delivery(Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-27) Farheen Fatima; SP22-R06-021; Dr. Muhammad Shahid Nazir; LHR TP 8660Metal organic frameworks are a class of porous materials having distinctive features such as large surface area, improved porosity, stability, and tunable structure. They exhibit diverse range of applications. MOFs can be surface engineered with different biomolecules or polymers to enhance stability, functionality, and biocompatibility. Recently, many MOFs have been explored for the application of drug delivery. However, MOFs as drug carriers still have some limitations like uncontrollable release of drug, cytotoxicity, and biocompatibility. To resolve the uncontrolled release problem, MOFs are conjugated with other materials for the fabrication of adsorbent materials, exhibiting desired properties and appropriate application. The aim of this work is to open new avenues for drug control release. Zeolitic Imidazole Framework-8 (ZIF-8) has improved structural porosity, flexibility, surface functionality and crystalline nature making it feasible to be utilized in the field of drug delivery. ZIF-8 is modified with cellulose to make it hydrophobic and to obtain aqueous stability. The biodegradability, higher surface area, and flexible binding interaction between the cellulose and ZIF-8 have made it an ideal choice for drug control studies. In order to enhance the properties ZIF-8 and cellulose is modified with TiO2 for biomedical purposes including biocompatibility, controlled release of drug and targeted drug delivery. The FTIR analysis shows a significant peak at 420cm-1 confirming the Zn-N bond along with peaks at 3648cm-1, 1940cm-1, 1345cm-1, and 1200 cm-1 confirming the O-H of the polymer, C=N vibration, C-N vibration of imidazole and C-O vibration of the composite. Peak at 650cm-1 corresponds to the N-Ti-O bond which confirms the incorporation of TiO2 ix particles inside the MOF structure. Moreover, XRD analysis shows characteristic peak positions at 23.03°, 25.77°, 38.14°, 48.55°, 54.28° and 55.57° confirming the presence of ZIF8, Cellulose and TiO2. Comparative drug release studies of ZIF-8 and modified ZIF-8 were performed at acidic, basic, and neutral pH with respect to time. The maximum release of 91% of cyclophosphamide was obtained under acidic conditions. This is because modified MOF makes strong linkages with the molecules of CP drug and therefore entangle with the molecules of drug owing to the addition of cellulose as well as TiO2.Item Antibacterial Functionally Graded Composite Membrane for Periodontal Regeneration(Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-23) Azka Shahid; FA19-R06-026; Dr. Sobia Tabassum; LHR TP 7318Periodontitis is a gum disease caused by bacterial infections. It damages the soft and hard tissues that clasped teeth position and leads to teeth loss. Periodontal disorder affects 90% of people throughout the world. A functionally graded membrane having mechanical strength, porosity, and good regeneration capability of hard and soft tissue of periodontal offers effective recovery In this study, an antibacterial, functionally, and structurally graded bilayer membrane was synthesized by using a greener crosslinker 2,3- dialdehyde cellulose (DAC). Chitosan (CH), Oval albumin (OA), and crosslinker DAC were used to fabricate the membrane for the soft tissue regeneration. The CH, OA Hydroxyapatite (HA), and Copper substituted hydroxyapatite (Cu-HA) were used to prepare membrane for the growth of hard tissue. To install antibacterial properties and improve biological activity in the proposed membrane HA was substituted with copper. The biopolymer used in this study possesses good regeneration ability. CS is the second most abundant natural biopolymer well known for its biocompatibility, bioactivity. Oval albumin reported to activate cellular adhesion and regenerations. Crosslinker dialdehyde cellulose offers good biocompatibility compared to commonly used toxic poly aldehyde-based crosslinkers. HA is a gold standard biomineral having an excellent ability to regenerate hard tissue. Oxidation of cellulose to dialdehyde cellulose was done by using NaIO4. Four different membrane samples with different amounts of crosslinkers were prepared to evaluate the effect of crosslinkers on membrane strength and biological properties. Prepared samples are named as M: DAC5%, M: DAC10%, M: DAC15%and M: DAC20%. Where M is represented CH and OA. Equal amount of both polymers was used. Crosslinker % was with respect to polymeric matrix. HA and CU-HA are synthesized via the economical co-precipitation method. FT-IR and XRD analysis showed the successful synthesis of HA and Cu-HA. XRD analysis also confirmed the phase pure preparation of Cu substituted HA crystal There is no secondary phase appeared in XRD spectra of HA and Cu-HA. EDS results also supported copper substitution. Porous membranes for hard tissues regeneration were prepared by using prepared HA or Cu-HA with CS and OA. The freeze gelation method was used for the fabrication of membranes. These membranes are named as is M: HA and M: Cu-HA. Two bilayer membranes were prepared by using M: DAC15% as a first layer and second layer M: HA or ME: Cu-HA. These samples are name as Bi-MDAC%15-HA and Bi-MDAC%15-CuHA. The second layer was fabricated over the first layer. Physical and biological tests of the membranes were performed to evaluate the performance of prepared membrane samples.