Department of Chemistry

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Author: search.filters.author.Dr. Muhammad YarSubject: search.filters.subject.FA19

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    2 Deoxy-D-ribose Releasing Sodium Alginate Based Hydrogels for Burn Wounds and Diabetic Ulcers
    (Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-25) SAFINA ABID; CIIT/FA19-R06-004/LHR; Dr. Muhammad Yar; LHR TP 7331
    2 Deoxy-D-Ribose has important biomedical applications due to its ability to stimulate angiogenesis, particularly in chronic and diabetic wound healing. The goal of this study was to see if manufactured tube hydrogel accelerates wound healing by stimulating angiogenesis in rats. 2 Deoxy-D-Ribose (2dDR), a small sugar, was loaded into sodium-alginate to produce a tube hydrogel. FTIR analysis confirmed the presence of sodium-alginate functional groups in freeze dried membranes. Drug release studied indicated that that approximately 98% of 2dDR was released between 1-7 days, that is beneficial for angiogenesis and wound healing. Antibacterial test revealed indicate that the sugar could not be metabolized by strains of E. Coli and Staphylococcus aureus. The rat models treated with alginate blank-Gel significantly promote wound healing and the 5% of 2 Deoxy-D-Ribose further significantly showed a rapid full thickness wound healing up to day 14 in contrast to untreated rat. Hair regeneration in rat model showed extensive hair follicle regrowth in 5% of 2 Deoxy-D-Ribose treated portion as compared to other groups. All these experiments confirm that these 2 Deoxy-D-Ribose (2dDR) tube hydrogel is suitable to use for stimulating angiogenesis and maintaining moist environment to accelerate wound healing applications
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    Collagen and PVA Crosslinked Material as Potential Candidate for the Development of Artificial Cornea
    (Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-23) Minahil Jaleel; FA19-R06-034; Dr. Muhammad Yar; LHR TP 7310
    The design and development of transparent membranes that provide good mechanical strength, water permeability, cell adhesion, less cytotoxicity and less degradation rate to cornea is a major challenge in corneal bioengineering. In current research, we fabricated collagen PVA based membranes by using different concentration of 2%, 4% and 6% of chemical crosslinker TEOF. Investigated the physical properties such as optical measurement, swelling studies, contact angle and degradation rates of membranes based on different concentration of TEOF. Results demonstrated that collagen PVA based membranes with 2% TEOF and 4% TEOF showed similar properties just like native cornea and it is a promising candidate for the development of artificial cornea for example contact angle of 2% TEOF and 4% TEOF are 54o and 570 respectively similar to the contact angle of cornea 590. These membranes showed good transparency and degradation properties.