Department of Chemistry

Permanent URI for this communityhttps://repository.cuilahore.edu.pk/handle/123456789/14

Browse

Author: search.filters.author.Dr. Muhammad YarSubject: search.filters.subject.Dr. Muhammad Yar

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    2 Deoxy-D-ribose Releasing Sodium Alginate Based Hydrogels for Burn Wounds and Diabetic Ulcers
    (Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-25) SAFINA ABID; CIIT/FA19-R06-004/LHR; Dr. Muhammad Yar; LHR TP 7331
    2 Deoxy-D-Ribose has important biomedical applications due to its ability to stimulate angiogenesis, particularly in chronic and diabetic wound healing. The goal of this study was to see if manufactured tube hydrogel accelerates wound healing by stimulating angiogenesis in rats. 2 Deoxy-D-Ribose (2dDR), a small sugar, was loaded into sodium-alginate to produce a tube hydrogel. FTIR analysis confirmed the presence of sodium-alginate functional groups in freeze dried membranes. Drug release studied indicated that that approximately 98% of 2dDR was released between 1-7 days, that is beneficial for angiogenesis and wound healing. Antibacterial test revealed indicate that the sugar could not be metabolized by strains of E. Coli and Staphylococcus aureus. The rat models treated with alginate blank-Gel significantly promote wound healing and the 5% of 2 Deoxy-D-Ribose further significantly showed a rapid full thickness wound healing up to day 14 in contrast to untreated rat. Hair regeneration in rat model showed extensive hair follicle regrowth in 5% of 2 Deoxy-D-Ribose treated portion as compared to other groups. All these experiments confirm that these 2 Deoxy-D-Ribose (2dDR) tube hydrogel is suitable to use for stimulating angiogenesis and maintaining moist environment to accelerate wound healing applications
  • No Thumbnail Available
    Item
    Collagen and PVA Crosslinked Material as Potential Candidate for the Development of Artificial Cornea
    (Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-23) Minahil Jaleel; FA19-R06-034; Dr. Muhammad Yar; LHR TP 7310
    The design and development of transparent membranes that provide good mechanical strength, water permeability, cell adhesion, less cytotoxicity and less degradation rate to cornea is a major challenge in corneal bioengineering. In current research, we fabricated collagen PVA based membranes by using different concentration of 2%, 4% and 6% of chemical crosslinker TEOF. Investigated the physical properties such as optical measurement, swelling studies, contact angle and degradation rates of membranes based on different concentration of TEOF. Results demonstrated that collagen PVA based membranes with 2% TEOF and 4% TEOF showed similar properties just like native cornea and it is a promising candidate for the development of artificial cornea for example contact angle of 2% TEOF and 4% TEOF are 54o and 570 respectively similar to the contact angle of cornea 590. These membranes showed good transparency and degradation properties.
  • No Thumbnail Available
    Item
    2-Deoxy-D-Ribose Releasing Chitosan/Collagen Based Pro-Angiogenic Skin Substitutes for Diabetic and Burn Wounds
    (Library Information Services COMSATS University Islamabad Lahore Campus, 2020-02-19) Muhammad Waqar Younas; SP19-R06-021; Dr. Muhammad Yar
    Chronic diabetic foot ulcers and severe burn injuries (i.e., full-thickness burns) cause extensive damage and are often complicated to heal and are burden on the economy. Slow or delayed blood vessel formation is the main reason for the delayed or non-healing of wounds [1]. It is estimated that in the year 2015 almost 8.8% of adult peoples were suffered from diabetes and the number of the diabatic patient is expected to increase at an alarming rate of 10.4% up to the year 2040 world-wide [2]. Diabetic patients suffer from non-healing wounds and the expanding rate of diabatic patients will increase the threats of chronic wounds. The development of cost-effective materials that can support angiogenesis is highly desired to prepare advance wound dressings [3]. In the current research, we developed the chitosan-based hydrogels through the freeze gelation method and utilized them as a 2-Deoxy-D-ribose (2dDR) carrier dressing. 2-Deoxy-D-ribose (2dDR) is a simple polysaccharide having ability to up regulate the release of VEGF in a more controlled way to support wound healing phenomenon in slow healing diabetic wounds [4]. Release studies of 2dDR were measured by using Bial’s orcinol assay. Swelling studies were performed to investigate the solution absorption capacity. Mechanical testing was performed to study the flexibility and tensile strength. Results indicated the developed material could be utilized as a cost-effective pro-angiogenic dressing material for diabetic and burn wounds.