Department of Chemistry
Permanent URI for this communityhttps://repository.cuilahore.edu.pk/handle/123456789/14
Browse
2 results
Search Results
Item Synthesis and Characterization of Injectable, Biocompatible and Biodegradable Hydrogels for Biomedical Application(Library Information Services COMSATS University Islamabad Lahore Campus, 2022-02-26) Muhammad Shumail; FA20-R06-013; Dr. Asma Tufail Shah; LHR TP 7883Periodontitis is a common oral infection that affects about 10-15% of global population. Periodontitis is characterized by gum inflammation, gingival recession, tissue loss, and dental pocket formation. Different approaches like tooth scaling, ultrasonic scalars, lasers, and root planning as well as surgical procedures have been employed but these mechanical treatments are limited and invasive. For tissue repair or wound healing, it is important to develop biomaterials which have ability of regeneration of bone tissues along with antibacterial properties and would be less invasive in nature. Injectable hydrogels are crucial in this area because they have mechanical and structural characteristics comparable to many body tissues and the artificial extracellular matrix (ECM) and can be delivered to the body in the least invasive manner. In this study a novel thermosensitive, injectable, biocompatible, and biodegradable Chitosan-Alginate based hydrogel was synthesized in combination with bioactive glasses. Different concentrations of primary polymers and copper substituted bioactive glasses were studied and characterized by employing various analytical techniques including XRD, FTIR, Contact Angle, Zetasizer and Inverted microscope. Gelation effect and setting time of these hydrogels were analyzed with and without Bioactive glass. The injectability of these biomaterials was tested via syringe needles of various gauges. Bioactivity and degradability studies were performed along with antibacterial applications against E. coli and S. aureus in which the hydrogels with copper substituted bioactive glass demonstrated positive anti-bacterial activity.Item Synthesis and Characterization of Metal Substituted Bioactive Glass for Treatment of Periodontal Disease(Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-25) Samreen Ashraf; FA19-R06-001; Dr. Asma Tufail Shah; LHR TP 7322Periodontitis is a serious gum infection that damages soft tissue and if not treated well can destroy bone resulting in tooth loss and is caused by different bacteria such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia. Roughly 50% world population is affected with it and 750 million people suffer from its severe form. The damaged bone can be regenerated in different ways, including using one’s own bone, or using donor’s bone and third way by using different synthetic bone fillers including bioactive glasses. Bioactive glasses (BGs) are non-crystalline biomaterials that are able to bond soft and hard living tissues and dissolve over time to stimulate growth of new tissues. In this research, an effective approach of periodontal treatment is to treat it with nano-sized bioactive glass prepared by co-precipitation method in which metal copper and fluoride ions are doped to increase its antimicrobial properties as well as strength. Different concentrations of copper-fluoride (Cu-F) doped bioactive glass have been prepared and characterized by different analytical techniques including FTIR, XRD and SEM-EDX to confirm the successful incorporation of copper and fluoride ions. The results showed that metal doped bioactive glasses were successfully prepared.