M.Phil / MS

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Fabrication Of Body Equivalent Tissue Phantom For The Evaluation Of Breast Cancer By Radiation Therapy
(Library Information Services, COMSATS University Islamabad, Lahore Campus, 2021) ABDUL MUGHNI; CUI/FA18-RPH-048/LHR; LHR TP 7245; Dr. Naima Amin
Preparing a phantom is a highly specialized testing object utilized in medical physics for dosimetry and evaluation of the effect of the dose distribution on cancer cells. The phantom is the best cancer investigational tool for the Medical Physicist. We will be preparing these phantoms to use as our training model. The phantom will be prepared like a real part of the human body tissues. The body or particular organ tissue-equivalent phantom was designed to minimize uncertainties in dosage measurements and treatment plan and also find the track followed by the high energy photon beam. After the preparation of our phantom, we investigate the center and surface doses by the radio-chromic film, it will be helpful in future research. The gel phantom will be irritated with the help of a photon beam and an electron beam of different energies. In this research, we will explore the diffusion of radiation in the irradiated part of the phantom and its effect on normal healthy cells of the phantom. These radiations aim to destroy a cancer cell's DNA. These radiation treatments usually include risks for adjacent healthy tissues within a f ew millimeters. Estimating ionizing radiation is important before cancer therapy. Breast cancer is reinduced by inappropriate radiation usage. Estimation of the radiation dosage may be made more precise for future treatment of any malignancy when the patient is repeatedly irradiated. The main difficulty in radiation treatment is providing a specified dosage to normal tissues. A severe lesion in healthy tissues may impede genome replication and transcription an d, if not corrected, lead to mutations that endanger the survival of cells or organs. Another aspect of this project is to revise the estimation and study of the dose calculation for further cancer treatment to keep safe the human body cells
Significance of Noise Reduction in Magnetic Resonance Imaging for Precise Diagnosis of Normal and Abnormal Tissues
(Library Information Services, COMSATS University Islamabad, Lahore Campus, 2020) Muhammad Awais Sardar; FA18-RPH-037; Dr. Naima Amin; LHR TP 6361
Over the past few decades with the invention and use of different medical imaging techniques like CT, MRI, Digital X-Ray and Angiography, its importance has already been proven by the ability of these techniques to diagnose and treat diseases. Medical images are usually low in quality, especially when it comes to image contrast
Dosimetric analysis of Rapid Arc (VMAT) treatment planning in head and neck cancer for quality assurance treatment
(Library Information Services, COMSATS University Islamabad, Lahore Campus, 2020) ATIKA FAROOQ; CUI/FA18 -RPH-041/LHR; Dr. Naima Amin; LHR TP 6095
neck cancer ,Diametric analysis of Rapid Arc (VMAT) treatment planning in head and neck cancer for quality assurance treatment Aim: Evaluate the plan of simultaneous integrated boost (SIB) fixed intensity modulated radiation therapy (IMRT) and SIB Rapid Arc using dosimetric indices. Material and Method: Twenty-nine patients of nasopharyngeal carcinoma (NPC) were taken for the plan evaluation of SIB rapid arc and SIB IMRT. The plan is evaluated by using conformity index (CI), target coverage (TC), gradient index (GI), external volume Index (EI), homogenity index (HI), dose heterogeneity index (DHI), standard deviation (SD) and unified dosimetric index (UDI). The dose of each planning target volume (PTV) is evaluated by using a mean and median dose of PTVs. The organ at risk dose (OAR) is evaluated by using the mean and maximum dose of OAR. The result is considered statistically significant, if p0.05. Result: CI, TC, GI, EI, and UDI is same for both rapid arc and IMRT. DHI of PTV 54 is better for IMRT as compared to rapid arc and DHI of PTV 60, and PTV 70 is same for both rapid arc and IMRT. HI, SD and sparing of OAR is better for rapid arc as compared to IMRT, The dose of PTV 54 and PTV 60 overdose. The dose of PTV 70 is within the limits of prescribed dose for both rapid arc and IMRT. Conclusion: Rapid arc homogenity, sparing of OAR and SD is better than IMRT. The consumption of time and monitor unit is reduced in the case of rapid arc. Hence, rapid arc is better than IMRT for the treatment of NPC.

M.Phil / MS

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