M.Phil / MS
Permanent URI for this collectionhttps://repository.cuilahore.edu.pk/handle/123456789/30
This collection archives the complete set of theses produced by students of the COMSATS University Islamabad, Lahore Campus.
Browse
2 results
Search Results
Item Synthesis and Characterization of Hybrid Mesoporous Silica Based Nanocarriers for Anti-Inflammatory Agents(Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-27) Husnain Haider; SP22-R06-015; Dr. Fozia Rehman; LHR TP 8654Mesoporous silica MCM-41 was synthesized using sol-gel method and functionalized with 3-aminopropyltriexthoxysilane and -N-(2-Aminoethyl)-3- aminopropyltrimethoxysilane to obtain surface functionalized materials MCM-A! and MCM-A2 respectively. The Fourier-transform infrared spectroscopy, NMR spectroscopy, XRD, nitrogen adsorption and desorption analysis and scanning electron microscopy were done for characterization of materials. The prepared materials were loaded with the anti-inflammatory drug Diclofenac (water soluble). The drug loading capacity of MCM-A1 and MCM-A2 were found as 21.6% and 26% respectively. The drug release profiles were constructed up to 75 hours. The results indicated that drug loaded materials showed distinct profiles and slow and controlled drug release was observed from these materials. The MCM-A1 showed a faster rate of drug release compared to MCM-A2, which is attributed to N-(2- Aminoethyl)-3-aminopropyltrimethoxysilane moieties attached to MCM-A2 surface resulting strong bonding interactions between the amine groups and drug molecules. By incorporating organic groups onto silica, the drug release rates could be tailored by varying the content of functional groups. The obtained results suggest that such extended drug delivery system may be used as controlled release cargos for water soluble anti-inflammatory drugs such as diclofenac sodium to enhance the drug safety and efficacy.Item Carbon Nanotubes and their Composites for Electrochemical Detection of Glucose(Library Information Services COMSATS University Islamabad Lahore Campus, 2020-02-19) Muhammad Umar Shakeel; FA18-R06-010; Dr. Abdur Rahim; LHR TP 6492Glucose plays a significant role in human body for energy generation and brain functioning. Human blood glucose level is a universal mark of an individual’s health particularly for the ones threatened with diabetes. Amid the rising number of affectees, various materials are being tested for incorporation in glucose sensing. An efficient and cost effective simple one step hydrothermal procedure for synthesis of cobalt selenide (CoSe) decorated carbon nanotubes using powdered selenium and hydrazine is reported with a feasible application of this advanced composite material as a novel binder free electrocatalytic material for glucose sensing and detection. A glassy carbon electrode deposited with the CoSe@CNTs shows eloquent excellence in application of glucose sensing exhibiting a lower limit of detection of 1.25 mM and an exceptionally high maximum current density of 6.8 ± 0.03 mA cm-2 in basic medium. Bulk electrochemical measurements performed with CoSe@CNTs loaded glassy carbon electrode also confirmed the oxidation of glucose in alkaline media