M.Phil / MS
Permanent URI for this collectionhttps://repository.cuilahore.edu.pk/handle/123456789/30
This collection archives the complete set of theses produced by students of the COMSATS University Islamabad, Lahore Campus.
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Item Synthesis and Characterization of TiO2/Cellulose@ZIF-8 for the Application of Drug Delivery(Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-27) Farheen Fatima; SP22-R06-021; Dr. Muhammad Shahid Nazir; LHR TP 8660Metal organic frameworks are a class of porous materials having distinctive features such as large surface area, improved porosity, stability, and tunable structure. They exhibit diverse range of applications. MOFs can be surface engineered with different biomolecules or polymers to enhance stability, functionality, and biocompatibility. Recently, many MOFs have been explored for the application of drug delivery. However, MOFs as drug carriers still have some limitations like uncontrollable release of drug, cytotoxicity, and biocompatibility. To resolve the uncontrolled release problem, MOFs are conjugated with other materials for the fabrication of adsorbent materials, exhibiting desired properties and appropriate application. The aim of this work is to open new avenues for drug control release. Zeolitic Imidazole Framework-8 (ZIF-8) has improved structural porosity, flexibility, surface functionality and crystalline nature making it feasible to be utilized in the field of drug delivery. ZIF-8 is modified with cellulose to make it hydrophobic and to obtain aqueous stability. The biodegradability, higher surface area, and flexible binding interaction between the cellulose and ZIF-8 have made it an ideal choice for drug control studies. In order to enhance the properties ZIF-8 and cellulose is modified with TiO2 for biomedical purposes including biocompatibility, controlled release of drug and targeted drug delivery. The FTIR analysis shows a significant peak at 420cm-1 confirming the Zn-N bond along with peaks at 3648cm-1, 1940cm-1, 1345cm-1, and 1200 cm-1 confirming the O-H of the polymer, C=N vibration, C-N vibration of imidazole and C-O vibration of the composite. Peak at 650cm-1 corresponds to the N-Ti-O bond which confirms the incorporation of TiO2 ix particles inside the MOF structure. Moreover, XRD analysis shows characteristic peak positions at 23.03°, 25.77°, 38.14°, 48.55°, 54.28° and 55.57° confirming the presence of ZIF8, Cellulose and TiO2. Comparative drug release studies of ZIF-8 and modified ZIF-8 were performed at acidic, basic, and neutral pH with respect to time. The maximum release of 91% of cyclophosphamide was obtained under acidic conditions. This is because modified MOF makes strong linkages with the molecules of CP drug and therefore entangle with the molecules of drug owing to the addition of cellulose as well as TiO2.Item Fabrication and Characterization of Reduced Graphene Oxide Decorated Doped Metal Oxide for Electrochemical Sensing of Diabetes Biomarkers(Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-23) Ayesha Kanwal; FA19-R06-028; Dr. Abdur Rahim; LHR TP 7329Glucose (C6H12O6), (H2O2) is one of the main biomolecules of our body. The alteration in the normal concentration gives rise to multiple disorders and diseases. The electrochemical measurements of glucose and hydrogen peroxide with the bare electrode is not possible due to various problem like electrochemical fouling, interference species have same oxidation potential and lower concentration of C6H12O6 and H2O2 in biological samples. The modification of the working electrode is essential for fast, accurate, selective, and sensitive detection of C6H12O6 and H2O2. Doped metal oxide/graphene oxide nanocomposites have attracted great attention due to the synergistic effect. The nanocomposites contain several properties such as catalytic activity, high surface area, electrochemical activity, and oxygen transferability which are attractive for sensor applications. In this work, a new hybrid material Gadolinium oxide/cobalt oxide/rGO (Gd2O3/Co3O4/rGO) nanocomposite was prepared by hydrothermal method. The nanocomposite was characterized by scanning electron microscopy (SEM, EDX, FTIR, Raman, XRD) for surface morphology, crystallinity, and elemental compositions study, and electrochemical techniques such as Cyclic Voltammetry, Impedance electrochemical and spectroscopy (EIS), Real Sample, Interference Study and Amperometry was used for senor evaluation. The synthesized material was used for the fabrication of biosensors. The Gd2O3/Co3O4/rGO nanocomposite was used for the surface modification of the glassy carbon electrode and tested as an electrochemical sensor for the detection of glucose and hydrogen peroxide. The proposed sensor gave good response for the detection of glucose and hydrogen peroxide. The sensor was also evaluated for the detection of glucose and hydrogen peroxide in the presence of co-existing species such as ascorbic acid, dopamine, folic acid, ethanol, and uric acid and did not show any interference in the results.