M.Phil / MS

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A Non-Enzymatic Dopamine Sensor Based on MoS2 Nanosheets Modified Carbon Cloth (CC) Electrode
(Library Information Services COMSATS University Islamabad Lahore Campus, 2020-02-20) Mariam Sabar; SP19-R06-002; Dr. Sara Riaz; LHR TP 6506
Dopaminergic neurons are the source of production of neurotransmitter called as dopamine (DA). It serves as chemical carrier in hormonal, renal, cardiovascular and central nervous system. The behavior of brain related with motivation and reward is controlled by dopamine in humans. The irregular level of dopamine results in many neural diseases which includes Alzheimer’s disease, less attention hyperactivity disease, Parkinson’s disease, schizophrenia as well as restless legs syndrome. It also gives information about probability of drug addiction. For that reason, an accurate method for the detection of dopamine is necessary. Here we described a material consisting of molybdenum disulfide nanosheets (MoS2 NSs) which were deposited on a Carbon Cloth (CC) electrode that is well adapted for sensitive and selective detection of level of dopamine. The molybdenum nanosheets deposited on CC was made by hydrothermal method. The composite was characterized with various characterization techniques like Scanning electron microscope (SEM), Cyclic Voltammetry, Fourier transform infrared spectroscopy (FTIR), Amperometric i-t method and electrochemical impedance spectroscopy. The composite represents excellent electrochemical properties like more electrochemically active surface, large capacitance current, more conductivity and more porosity as shown by different electrochemical studies. The carbon cloth electrode shows good electrocatalytic ability for dopamine oxidation. The electrode operated best at working potential as low as -0.2 V (vs. Ag/AgCl). It responds linearly to dopamine within 0.25mM to 4mM concentration. The sensor has good selectivity, better stability, repeatability and reproducibility.
A DFT Study of Dopamine Functionalized Borospherenes for Effective Cancer Treatment
(Library Information Services COMSATS University Islamabad Lahore Campus, 2020-02-19) Iqra Karim; SP19-R06-003; Dr. Sobia Tabassum; LHR TP 6507
Cancer has become one of the major threats to human life. Cancer therapies also bear the risk to health tissues. An effective approach to safe health cells is the integration of photothermal properties in the targeted chemotherapeutic system. In the present study, the targeted drug-carrying capacity of dopamine functionalized borospherene has been explored with the help of DFT. The results reveal that functionalization has a strong influence on geometrical, electronic, and thermodynamic properties of borospherene. The drug-loaded on functionalized borospherene has reduced the bandgap up to 2.104 eV. The reduction in band gap is fully supported by the density of states. The thermodynamic data confirms the exothermic and spontaneous nature of adsorption. NBO analysis confirms the charge transfer from drug and dopamine towards borospherene. Functionalization of dopamine extraordinarily increases the molecular descriptors parameters. The softness and electrophilicity index values increased for the drug-loaded on functionalized borospherene to 0.48 eV and 7.51 eV respectively. Similarly, the dipole moment also increases from 11.86 Debye to 21.94 Debye increasing the polarity. Moreover, the values of chemical hardness and chemical potential decrease from 1.45 eV to 1.05 eV and -3.71 eV to -3.97 eV respectively. This shows improved stability and reactivity of the functionalized borospherene than the drug load on pristine borospherene. All these are favorable drug delivery capacity of functionalized borospherene system. The SERS-Raman spectrum of functionalized borospherene shows more intense peaks at 1500-2000 cm- 1 and 3000-4000 cm-1 than the drug-loaded on pristine borospherene which has one intense peak at 1500-2000 cm-1. It means that functionalization improves the detection of the drug. Similarly, UV spectrum also shows that the maximum absorption increases from wavelength 501 nm to 581 after functionalization and a weak signal also appears at 703 nm.
Non-Enzymatic Electrochemical Sensing of Dopamine based on Transition Metal Oxides/CNTs
(Library Information Services COMSATS University Islamabad Lahore Campus, 2020-02-17) Shamim Ramzan; FA18-R06-009; Dr. Abdur Rahim; LHR TP 5963
Sensing with the aid of metal oxides and CNTs is the most vibrant field of electrochemical science, which endows an ambit for various innovative and novel functions with a variety of applications. Enzymatic sensors are costly, lack of stability, have difficult immobilization techniques as well as electrodes used for electrochemical analysis of neurotransmitter concentrations are also unable to monitor the potential of these species. Besides, sensors with the most robust and reliable electrodes generally tend to deteriorate over months of use. Therefore, a study has been designed to synthesize CNTs based metal oxides nanoparticles by green synthesis method using the lignin as a modifier and reducing agent. The synthesize materials have been characterized by different techniques, i.e. SEM, XRD, and FTIR for surface morphology, determination of nanostructure, and functionalization of surface. The synthesized materials such as C2O3@CNTs/lignin, and CuO@CNTs/lignin have been used for the surface modification of glassy carbon electrode (GCE). These composites are supposed to be used as a promising material for dopamine sensing by giving excellent electrochemical properties.

M.Phil / MS

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