M.Phil / MS
Permanent URI for this collectionhttps://repository.cuilahore.edu.pk/handle/123456789/30
This collection archives the complete set of theses produced by students of the COMSATS University Islamabad, Lahore Campus.
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Item Identification of Bioactive Phytoconstituents from Anti-hemorrhagic Herbal Mixture(Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-26) Ali Hamza Sajid; FA21-R06-028; Dr. Muhammad Javid Iqbal; LHR TP 8458Plants are essential for human well-being, providing vital resources and medicinal benefits. This study focused on a herbal mixture comprising Nigella sativa (40%), Cassia senna (20%), Oscimum basilicum (20%), and Mentha piperita (20%), investigating their synergistic potential as anti-inflammatory and anti-angiogenic agents. Chronic ailments activate inflammatory and angiogenic pathways, causing swelling, pain, and bleeding. Synthetic drugs have limitations, while herbal medicines offer a safer alternative research Current studies aimed to find effective and safe phytoconstituents to replace synthetic drugs. Different extracts were obtained through sequential extraction using petroleum ether, chloroform, and methanol. Phytochemical screening confirmed the presence of key chemical constituents. HPLC confirmed that methanol extracts contained polyphenolic compounds such as quercetin, gallic acid, vanillic acid, syringic acid, m-coumaric acid, and sinapic acid, while the chloroform extracts contained phenolic compounds including quercetin, vanillic acid, benzoic acid, chlorogenic acid, p-coumaric acid, and cinnamic acid. The antiangiogenic activity of extracts was evaluated using the CAM assay. The methanol extracts at 1000μg/ml showed significant antiangiogenic activity with a 57.91% inhibition rate. The 500μg/ml concentration also showed significant potential with a 39.56% inhibition rate. The high dose of the chloroform extract displayed significant results, while the petroleum ether extract did not show significant effects. The positive control, Sorafenib, exhibited a significant inhibition rate of 55.89%. The anti-inflammatory activity was evaluated using the carrageenan-induced hind paw edema test. The 500mg/kg dose of the methanol and chloroform extracts showed significant anti-inflammatory effects, with inhibition rates of 93.49% and 78.35% respectively after 120 minutes. At 90 minutes, the methanol extract exhibited an inhibition rate of 86.79%, while the chloroform extract showed an inhibition rate of 71.84%. The 250mg/kg concentration of both extracts also displayed significant anti-inflammatory activity. The petroleum ether extract exhibited moderate anti-inflammatory activity only at the 500mg/kg concentration. Overall, the results highlighted the superior synergistic anti-inflammatory and anti-angiogenic potential of the methanol and chloroform extracts in comparison to the petroleum ether extract, suggesting their suitability for the development of natural anti-inItem Synthesis of Versatile Bio Adsorbent from Wheat Bran based Biomaterials to Clean Textile Wastewater(Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-26) Atiya Mukhtar; FA21-R06-001/LHR; Dr. Muhammad Javid Iqbal; LHR TP 8439Textile industry is of the biggest water consumption industries globally which is generating a significant amount of wastewater with high level of pollutants. Outflow of textile effluent is a major issue in this era and it is becoming the considerable problem and health disasters for humans and other livings. The presented work is basically on the synthesis of unmodified and modified wheat bran as bio adsorbent material. The efficacy and adsorption capacity have increased significantly with activated charcoal and highlighted its application by using different parameters and frameworks for removal of CBB textile dyes have been tested. Commassie Brilliant blue dye has largely been used for staining and dying on protein fabric in textile industry. Removal of toxic dyes from textile wastewater in a modal water system has been checked experimentally for the efficiency of laboratory developed bio adsorbent. Several parameters were used like pH change, adsorbate concentration, adsorbent concentration, temperature and time and by changing these parameters significant variations were observed through % removal of CBB dye. For the characterization of mesostructured wheat bran and activated charcoal before and after adsorption by FTIR technique, UV-visible spectroscopy was used to measure absorption and find out percentage adsorption or removal of dye in wastewater samples.XRD was used to investigate average crystalline size. Bio adsorbent have removed 97% of organic dye named CBB R-250g through unmodified and modified wheat brans which proved good adsorption and reusability for minimum 0.1g/100ml of solution. This ecofriendly bio adsorbent can be used in bulk for cleaning the textile wastewater on industrial scale economically. In future, mega projects of cleaning waste water may be initiated in cosmopolitan areas by local Government municipality.