M.Phil / MS
Permanent URI for this collectionhttps://repository.cuilahore.edu.pk/handle/123456789/30
This collection archives the complete set of theses produced by students of the COMSATS University Islamabad, Lahore Campus.
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Item Synthesis and Characterization of Metal Substituted Bioactive Glass for Treatment of Periodontal Disease(Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-25) Samreen Ashraf; FA19-R06-001; Dr. Asma Tufail Shah; LHR TP 7322Periodontitis is a serious gum infection that damages soft tissue and if not treated well can destroy bone resulting in tooth loss and is caused by different bacteria such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia. Roughly 50% world population is affected with it and 750 million people suffer from its severe form. The damaged bone can be regenerated in different ways, including using one’s own bone, or using donor’s bone and third way by using different synthetic bone fillers including bioactive glasses. Bioactive glasses (BGs) are non-crystalline biomaterials that are able to bond soft and hard living tissues and dissolve over time to stimulate growth of new tissues. In this research, an effective approach of periodontal treatment is to treat it with nano-sized bioactive glass prepared by co-precipitation method in which metal copper and fluoride ions are doped to increase its antimicrobial properties as well as strength. Different concentrations of copper-fluoride (Cu-F) doped bioactive glass have been prepared and characterized by different analytical techniques including FTIR, XRD and SEM-EDX to confirm the successful incorporation of copper and fluoride ions. The results showed that metal doped bioactive glasses were successfully prepared.Item Synthesis of Biomolecule Loaded Bioactive Glass and its Antibacterial Properties(Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-24) Syed Bilal Hasan; FA19-R06-025; Dr. Asma Tufail Shah; LHR TP 7535Bioactive glasses (BGs) are synthetic bone fillers that have ability to replace damaged bone, facilitate tissue regeneration and integrate with body environment. In this study we used bioactive glass prepared by co-precipitation method and used doxycycline as a biomolecule. Doxycycline (DOX) was loaded on bioactive glass with different concentrations (2mg/mL, 4mg/mL and 8mg/mL). Both, simple BG and BG/DOX was characterized using Fourier Transform Infrared spectrophotometer (FTIR), X-Ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). Antibacterial studies were conducted against E. Coli and S. Aureus bacteria. The results showed that BG/DOX was affective against these bacterial strains as they inhibited their growth. The zone of inhibition was 19.5mm, 26mm, 26.5mm and 22.5mm, 28mm, 24mm for BG/DOX-2, BG/DOX-4 and BG-DOX-8 against E. coli and S. aureus respectively. There was not much difference in zone of inhibition by changing concentration from 4mg to 8mg. Hence, 4mg is considered as an optimum concentration. Therefore, Doxycycline drug loaded BGs can be used to enhance the antibacterial properties of BGs, in tissue engineering applications, and in root implants of teeth's for long term effect.