Browsing by Author "Rida Fatima"

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In silico Identification of Forsythiae fructus Ingredients and Mechanistic Investigation of its Effect against Neuronal Injury
(Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-24) Rida Fatima; FA19-R06-018; Dr. Ghulam Murtaza; LHR TP 7341
Purpose: Neuronal damage is a serious medical disorder that affects the entire universe population. Traditional Chinese Medicines have a multifarious-target, multifarious-component and multifrious-pathway mechanism for treating ailments. Traditional Chinese Medicine Forsythiae fructus have neuroprotective properties. It is a clinical based herb used for the treatment of neuronal injury but its action mechanism is still uncertain. The goal of this study is to use network pharmacology to understand the underlying mechanism of Forsythiae fructus in treating neuronal damage. Methodology: According to the literature of Forsythiae fructus chemical ingredients and targets were searched using TCMSP database. Afterwards, protein-protein interaction network was constructed through STITCH database. Then pathways were analyzed through GO enrichment analysis using plugin-ClueGO. Results: Total number of active ingredients were found to be 38 associated with 145 targets. The screening of these targets resulted in the identification of 17 targets that are linked to neuronal damage. The investigation of GeneOntology (GO) and pathway enrichment yielded a total of 261 GO terms. The main hubs such as MAPK1, AKT1, Estrogen, Estradiol, ESR1, SRC, CREBBP and SP1 were found to be associated with neuronal injury. Molecular docking of arctiin, beta-sitosterol, hyperforin, kaempferol, phyllirin and quercitin demonstrated minimum docking score with the targets AKT1, ESR1 and SRC. Conclusion: The results suggest that Forsythiae fructus could be very effective in the treatment of neuronal injury. The results also suggested that beta-sitosterol and quercitin have a good affinity with AKT1 against neuronal injury.
Requirement Change Prediction Model For Small Software systems
(Library Information Services, COMSATS University Islamabad, Lahore Campus, 2020) Rida Fatima; FA18-RCS-025; LHR TP 6416; Dr. Farrukh Zeshan
The software industry is rising gradually, it seems that there is no end to software development. Modern era software projects are complex and consist of many components, so change is unavoidable in these projects. Therefore, change in the software requirements document must be predicted at an early stage to preserve the resources. There are a lot of requirement change prediction models proposed in the literature and they are addressing a smaller number of variables and including experts knowledge for analyzing the requirement specification document. In this work, we have focused on the small software systems which have focused few variables of requirement change prediction model.The variables have a major effect on the software requirements and these are analyzed by the stakeholders, developers and experts with the questionnaire method. Their knowledge is incorporated in the Bayesian network as conditional probabilities of independent and dependent variables.This is actually the proposed model for software requirements change prediction.We used an algorithm with the model by utilizing variable elimination method to obtain the posterior probability of the revisions in software requirement document. However this model can also be used for the large software systems because it is effecent to resolve their problems also. the The proposed model is evaluated by hypothesis testing, sensitivity analysis and by comparing with the existing models. The results obtained proved to be promising as it decreases the probability of revisions in the requirement document. We obtained the 0.42 probability for the revisions in the requirement document so the results have improved the existing model predictions
Social Identity Construction in Migration Narrative: A Critical Stylistic Analysis of Mohsin Hamid’s Exit West
(Library Information Services, COMSATS University Islamabad, Lahore Campus, 2020) Rida Fatima; FA18-REL-001; Dr. Aasia Nusrat; LHR TP 5998
This thesis analyzes the construction of social identity in the migration narrative of Mohsin Hamid’s Exit West (2017) with a special focus on the engagement of text with the identity construction by using tools of textual conceptual functions from Lesley Jefferie’s Critical Stylistics (2010) for codification and Laclau and Mouffe’s Political Discourse Theory (2010). This study explores the ways that how the migrant characters engage with these concepts and how their representation destabilizes the dominant and traditional meaning of identity. For the migrant protagonists in Exit West (2017), the notion of identity is not strictly defined in relation to their place of origin or to any affiliation with a particular place. In other words, the narrative in the text is centered on the fact that although the migrants initially define identity in strict association to their homeland or place of origin, this subsequently changes as they move out of their city of birth and encounter various places and cultures. In the Findings section, this study shows the identity issues of the migrant characters and their problems in social spheres
Social Identity Construction in Migration Narrative: A Critical Stylistic Analysis of Mohsin Hamid’s Exit West
(Library Information Services, COMSATS University Islamabad, Lahore Campus, 2020) Rida Fatima; FA18-REL-001; Dr. Aasia Nusrat; LHR TP 5998
This thesis analyzes the construction of social identity in the migration narrative of Mohsin Hamid’s Exit West (2017) with a special focus on the engagement of text with the identity construction by using tools of textual conceptual functions from Lesley Jefferie’s Critical Stylistics (2010) for codification and Laclau and Mouffe’s Political Discourse Theory (2010). This study explores the ways that how the migrant characters engage with these concepts and how their representation destabilizes the dominant and traditional meaning of identity. For the migrant protagonists in Exit West (2017), the notion of identity is not strictly defined in relation to their place of origin or to any affiliation with a particular place. In other words, the narrative in the text is centered on the fact that although the migrants initially define identity in strict association to their homeland or place of origin, this subsequently changes as they move out of their city of birth and encounter various places and cultures. In the Findings section, this study shows the identity issues of the migrant characters and their problems in social spheres
Synthesis and Characterization of Conducting Filler-Based Elastomer Composites for Electromagnetic Shielding Applications
(Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-27) Rida Fatima; SP22-R06-013; Prof. Dr. Zulfiqar Ali; LHR TP 8652
The evolution of advanced communications systems and other electro-electronic gadgets has led to a type of electromagnetic pollution that has an impact on both the functionality of other equipment and people's health. There is a growing need for effective shielding materials to control EMI and related issues. A variety of composite materials have been developed using various combinations of dissimilar elements because it is widely known that single configuration cannot achieve necessary materials EMI-shielding (EMI-S) efficacy. The most popular materials having EMI shielding materials are made of metals with having inherent flaws including being heavy, more prone to corrosion, expensive, complex to produce, etc. Shields with to overcome these constraints, metal-based structure was modified using a variety of structural types and other materials. Conducting polymer-based composites have distinguished themselves from other classes of materials that form composite produced as Shielding-EMI components due to unique characteristics such as lower weight, environmental stability, long-life, durability, and minimal corrosive tenability. Here, in this work, Conducting Filler-Based Elastomer Composites synthesized and characterized by melt mixing method for electromagnetic shielding applications. The surface modification confirmed by different characterization techniques i.e., Fourier-transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). For the mechanical and EMI Shielding applications composites material characterized by Universal testing machines (UTMs) that test mechanical properties such as tensile, flexural, compressive and shear. Thermogravimetric analysis (TGA) analysis for the measurement of thermal stability of material electrical conductance measurement and use of Vector Network Analyzer by Rhode and Shwarz for EMI Shielding.