Browsing by Author "Prof. Dr. Anila Asif"

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    Design and Development of Electrospun Membranes Loaded with Novel Nanoparticles for Wound Healing
    (Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-26) Hafsa Azhar; FA21-R06-026; Prof. Dr. Anila Asif; LHR TP 8456
    This research study investigated the design and development of electrospun membranes loaded with novel nanoparticles for wound healing. The primary focus of this work was to address the challenges associated with wound dressings, with the need for enhanced wound healing, optimization of electrospun membranes, and sustained release of drugs. To achieve these goals, electrospun membranes composed of polymers such as cellulose acetate, polyurethane (PU), and polyvinyl alcohol (PVA) were fabricated. Nanoparticles of ciprofloxacin were incorporated into the electrospun membranes to impart additional functionalities and promote wound healing. The methodology employed two key techniques: electrospinning and the ion gelation method. Electrospinning was used to fabricate the membranes, providing control over key properties such as pore size, mechanical strength, porosity, and morphology. The ion gelation method was utilized for the synthesis of chitosan-ciprofloxacin nanoparticles, which were subsequently loaded into the electrospun membranes. The comparison of sheets with free ciprofloxacin and nanoparticles of ciprofloxacin was carried out in this study. Characterizations of the membranes and nanoparticles were performed using FESEM, FTIR, XRD, TGA, density measurements, contact angle measurements, antibacterial studies and drug release. These analyses allowed for the assessment of morphology, chemical composition, crystallinity, thermal stability, and surface wettability of the materials.
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    Fabrication of Antibacterial Cellulose-Chitosan Based Hydrogels to Promote Wound Healing
    (Library Information Services COMSATS University Islamabad Lahore Campus, 2020-02-19) Hina Khadim; SP19-R06-010; Prof. Dr. Anila Asif; LHR TP 6538
    Cellulose-chitosan based hydrogels containing eugenol were synthesized and various properties were studied. Eugenol was used to incorporate antibacterial efficacy necessary for wound healing. Four different compositions of the hydrogels were prepared. CS.OMCC 1:1, CS.OMCC 2:1, CS.OMCC 4:1 and CS.MCC 2:1 showed effective antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). CS.OMCC 4:1 showed the largest inhibition zone against both the bacterial strains because it had more chitosan content. The diameters of inhibition zones increased as the chitosan content in the hydrogels increased. The degree of swelling (in PBS) and in vitro degradation (in PBS and PBS+lysozyme solutions) have been investigated. CS.OMCC 1:1 hydrogel showed maximum swelling. CS.OMCC 1:1 showed good percent degradation of 42 and 56.8% in PBS and PBS+lysozyme, respectively. The pH variations have been monitored during the degradation studies in PBS and lysozyme. Fourier transform infrared spectroscopy (FTIR) has been carried out to elucidate structural properties of all synthesized hydrogels. Thermogravimetric analysis of the synthesized hydrogels was also carried out. Overall, a natural, antibacterial hydrogel, resistant to E. coli and S. aureus has been synthesized. The composite hydrogels CS.OMCC 1:1 and CS.OMCC 4:1 were the most suitable compositions for their application in wound healing.