Browsing by Author "Dr. Mustansara Yaqub"

Now showing 1 - 3 of 3

Antibacterial Drug-Loaded Stimuli-Responsive Electrospun Thin Films for Wound Healing
(Library Information Services, COMSATS University Islamabad, Lahore Campus, 2025) Sawera Malik; CIIT/SP24-R06-015/LHR; Dr. Mustansara Yaqub; LHR TP 10021
This study reports the preparation of pH-sensitive electrospun composite membranes, made of Eudragit L100 and hydroxypropyl methylcellulose (HPMC), and loaded with ciprofloxacin, to heal an infected wound. These membranes had a bead-free, uniform nanofibrous and microfibrous structure with fiber diameter of 633nm and 1.79μm. Introduction of the antibiotic resulted in significant improvement in hydrophilicity with a contact angle reduced from 76.98° to 64.56°, and swelling capacity increased about 430% and thus facilitating absorption of the wound exudate and maintaining a damp microenvironment that allows tissue regeneration. The membranes showed 5.6MPa maximum stress with 3.4% strain in dry conditions and 1.1MPa stress with 12% strain in wet conditions. At pH 7.4, more than 75% membrane is degraded, while at pH 5.6, less than 10% is degraded in 14 days. The drug release at pH 7.4 is almost 77% and less than 20% at pH 5.6. These composite membranes showed pH-dependent degradation and drug-release kinetics.
MOF Based Electrochemical Sensor for the Detection of Antimicrobial Drug Residues in Food Stuff
(Library Information Services COMSATS University Islamabad Lahore Campus, 2021-02-23) HAFIZA KHADIJA ASLAM; FA19-R06-013; Dr. Mustansara Yaqub; LHR TP 7313
With the increasing unregulated use and toxicity of antimicrobials to public health and increase in bacterial resistance, it has become a major challenge to design a sensitive, rapid and cost effective technique to detect antimicrobials in food stuff. This research work describes the electrochemical detection of Metronidazole (MTZ) drug residues by using Silver Carbon dots embedded Cu-Gallic acid nanocomposite, coated at GCE (Ag/CDs@CuGA MOF/GCE). Pomegranate peels were used as a green and cost effective source to produce Carbon dots (CDs) and an aqueous oven assisted –solvothermal technique was chosen to fabricate the nanocomposite. Moreover, its crystal, elemental structure and morphological aspects were studied. The electrochemical properties of synthesized nanocomposite were analyzed to examine the nanocomposites sensitivity towards electro-catalytic determination of Metronidazole (MTZ). It was concluded that Silver Carbon dots embedded Cu-Gallic acid nanocomposite, coated at GCE (Ag/CDs@CuGA MOF/GCE) exhibits tremendous electro-catalytic properties toward Metronidazole (MTZ) reduction. A rapid, sensitive, reproducible and cost effective electrochemical sensor was developed which enables to sense the concentrations of drug at lower levels. The fabricated sensor had also shown good results even in real sample analysis (tetra pack milk and fresh milk).
Sensing Platform based on Metal Organic Framework for the Quantitative Determination of Antibiotic Remains in Animal Derived Food
(Library Information Services COMSATS University Islamabad Lahore Campus, 2023-02-26) FA21-R06-017; Ameer Hamza; Dr. Mustansara Yaqub; LHR TP 8448
In this pioneering research work, we have successfully synthesized a highly advanced Copper Gallic Acid-L-Arginine Metal-Organic Framework (Cu-Gallic Acid-L-Arginine MOF) and ingeniously engineered it into an extraordinary electrochemical sensor, enabling the unparalleled sensitivity in the detection of chloramphenicol (CAP). To validate the successful formation of the Cu-Gallic Acid-L-Arginine MOF, a comprehensive array of cutting-edge characterization techniques including Scanning Electron Microscopy (SEM), UV-Vis Spectroscopy, Fourier-Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), and Zeta potential analysis were meticulously employed. To evaluate the exceptional electrochemical properties of the Cu-MOF-based sensor, Electrochemical Impedance Spectroscopy (EIS) and Cyclic voltammetry (CV) were utilized, providing deep insights into its performance. Furthermore, the Cu-MOF-modified Pencil Graphite Electrode (PGE) demonstrated excellent detection proficiency in the presence of chloramphenicol. The performance of the developed sensor was truly remarkable, showcasing an extensive linear detection range from 1nM to 1000nM, along with an astonishingly low detection limit of 0.36nM (S/N = 3). Moreover, this highly promising sensor showcased exceptional sensitivity, robust stability, impressive repeatability, and a commendable recovery rate for the electrochemical detection of CAP in real samples. These ground-breaking findings elevate the Cu-Gallic Acid-L-Arginine MOF-based sensor to an unprecedented level, positioning it as a leading-edge technology for CAP detection, and underscoring its immense potential in diverse applications.