Abstract:
Due to rapidly increasing neurological disorder, there is a continuous need for the
development of rapid and accurate diagnosis methods. An electrochemical biosensor
fabrication is involved in this research project which is done by the modification of
screen printed electrode with rGO/Co3O4/Chitosan nanobiocomposite. This biosensor
was used for the detection of Norepinephrine neurotransmitter whose abnormal level
leads to depression that is a major risk factor for neurological disorders. Chitosan based
nanocomposites are widely used in the fabrication of biosensors all thanks to its
biocompatible, biodegradeable and non toxic properties.
Graphene Oxide was prepared by modified Hummers method, rGO/Co3O4
nanocomposite was prepared by one step hydrothermal method, and rGO/Co3O4/Chitosan
nanobiocomposite was prepared by solution mixing technique. At the end to fabricate a
biosensor, SPE was modified with prepared nanobiocomposite by drop casting method.
The as prepared material was characterized by Raman spectroscopy, FTIR, XRD and
SEM. The electrochemical response was checked by cyclic voltammetry and
electrochemical impedance spectroscopy.
