Abstract:
This research study investigated the design and development of electrospun membranes
loaded with novel nanoparticles for wound healing. The primary focus of this work was
to address the challenges associated with wound dressings, with the need for enhanced
wound healing, optimization of electrospun membranes, and sustained release of drugs.
To achieve these goals, electrospun membranes composed of polymers such as cellulose
acetate, polyurethane (PU), and polyvinyl alcohol (PVA) were fabricated. Nanoparticles
of ciprofloxacin were incorporated into the electrospun membranes to impart additional
functionalities and promote wound healing. The methodology employed two key
techniques: electrospinning and the ion gelation method. Electrospinning was used to
fabricate the membranes, providing control over key properties such as pore size,
mechanical strength, porosity, and morphology. The ion gelation method was utilized for
the synthesis of chitosan-ciprofloxacin nanoparticles, which were subsequently loaded
into the electrospun membranes. The comparison of sheets with free ciprofloxacin and
nanoparticles of ciprofloxacin was carried out in this study. Characterizations of the
membranes and nanoparticles were performed using FESEM, FTIR, XRD, TGA, density
measurements, contact angle measurements, antibacterial studies and drug release. These
analyses allowed for the assessment of morphology, chemical composition, crystallinity,
thermal stability, and surface wettability of the materials.
