Abstract:
In this pioneering research work, we have successfully synthesized a highly advanced
Copper Gallic Acid-L-Arginine Metal-Organic Framework (Cu-Gallic Acid-L-Arginine
MOF) and ingeniously engineered it into an extraordinary electrochemical sensor, enabling
the unparalleled sensitivity in the detection of chloramphenicol (CAP). To validate the
successful formation of the Cu-Gallic Acid-L-Arginine MOF, a comprehensive array of
cutting-edge characterization techniques including Scanning Electron Microscopy (SEM),
UV-Vis Spectroscopy, Fourier-Transform Infrared Spectroscopy (FT-IR), X-ray
Diffraction (XRD), and Zeta potential analysis were meticulously employed. To evaluate
the exceptional electrochemical properties of the Cu-MOF-based sensor, Electrochemical
Impedance Spectroscopy (EIS) and Cyclic voltammetry (CV) were utilized, providing
deep insights into its performance. Furthermore, the Cu-MOF-modified Pencil Graphite
Electrode (PGE) demonstrated excellent detection proficiency in the presence of
chloramphenicol. The performance of the developed sensor was truly remarkable,
showcasing an extensive linear detection range from 1nM to 1000nM, along with an
astonishingly low detection limit of 0.36nM (S/N = 3). Moreover, this highly promising
sensor showcased exceptional sensitivity, robust stability, impressive repeatability, and a
commendable recovery rate for the electrochemical detection of CAP in real samples.
These ground-breaking findings elevate the Cu-Gallic Acid-L-Arginine MOF-based sensor
to an unprecedented level, positioning it as a leading-edge technology for CAP detection,
and underscoring its immense potential in diverse applications.
