Abstract:
Metallic nanoparticles are well known for their biomedical applications including
antimicrobial activity and wound dressing materials due to large surface to volume ratio
and other chemical properties. In this work, gold doped tin oxide (Au-SnO2) nanoparticles
containing chitosan-based porous membranes were prepared by the freeze-gelation
method. Hydrogel membranes were prepared using the blending of natural polymers and
loading metallic nanoparticles as an antibacterial agent. The different membranes were
prepared using the different concentrations of metallic nanoparticles by the freeze-gelation
process, during this process Triethyl Orthoformate (TEOF) used as a cross-linker agent.
This different concentration of membranes were tested for bactericidal potential using the
disk diffusion method. Further, swelling studies of these membranes were performed in
PBS solutions. The presence of Au-SnO2 NPs were confirmed by the scanning electron
microscopy (SEM) analysis. The Fourier Transform Infrared Spectroscopy (FTIR) analysis
confirmed the presence of the chitosan functional group. All these experiments confirmed
that these membranes are safe to use for wound dressing material and other biomedical
applications.
