Abstract:
Metallic Np`s are well known for biological applications as well as antimicrobial activity and
wound dressing materials. As an alternative to antibiotics, nanoparticles (NPs) are
increasingly being employed to target bacteria. Antibacterial coatings for implantable devices
and promote wound healing and medicinal materials to prevent infection, bacterial detection
systems to generate microbial diagnostics, antibiotic delivery systems to treat disease, and
antibacterial vaccines to control bacterial infections are all examples of NP applications.
Gold doped zirconium oxide (Au-ZrO2) was used in this study. For antibacterial properties,
gold doped ZrO2 NPs were produced using a co-precipitation technique. The antibacterial
test was carried out using the well diffusion method. The zone of inhibition against E. coli
and S.aureus was measured. Higher gold doping concentrations result in a broader inhibition
zone against gram positive and gram-negative microorganisms. Fourier Infrared Transform
Spectroscopy (FTIR), X-Ray diffraction (XRD), Raman spectroscopy, and Scanning
Electron Microscopy were used to analysis the produced nanoparticles (SEM). The existence
of the ZrO2 functional group is explained by FTIR analysis and crystalline structure is
determined by XRD. Raman spectra also confirm the optical and vibrational phonons and
magnons present in ZrO2. SEM corroborated the morphology of nanoparticles.
