Abstract:
2 Deoxy-D-Ribose has important biomedical applications due to its ability to stimulate
angiogenesis, particularly in chronic and diabetic wound healing. The goal of this study was to see
if manufactured tube hydrogel accelerates wound healing by stimulating angiogenesis in rats. 2
Deoxy-D-Ribose (2dDR), a small sugar, was loaded into sodium-alginate to produce a tube
hydrogel. FTIR analysis confirmed the presence of sodium-alginate functional groups in freeze
dried membranes. Drug release studied indicated that that approximately 98% of 2dDR was
released between 1-7 days, that is beneficial for angiogenesis and wound healing. Antibacterial
test revealed indicate that the sugar could not be metabolized by strains of E. Coli and
Staphylococcus aureus. The rat models treated with alginate blank-Gel significantly promote
wound healing and the 5% of 2 Deoxy-D-Ribose further significantly showed a rapid full thickness
wound healing up to day 14 in contrast to untreated rat. Hair regeneration in rat model showed
extensive hair follicle regrowth in 5% of 2 Deoxy-D-Ribose treated portion as compared to other
groups. All these experiments confirm that these 2 Deoxy-D-Ribose (2dDR) tube hydrogel is
suitable to use for stimulating angiogenesis and maintaining moist environment to accelerate
wound healing applications
