Abstract:
For tissue repair or wound healing, it is important to develop a biomaterial which
would have such qualities that make it most suitable for the skin and the tissues.
Lacto-bionic acid having properties like, anti-oxidant, anti-aging and anti-bacterial
was expected to be better choices for developing such hydrogel that not only heals or
repair the tissue but also provides skin care. Using different concentrations of Lactobionic acid, an anti-bacterial, thermo-sensitive injectable hydrogel was prepared.
Lacto-bionic acid having anti-bacterial properties was used in varied concentrations to
form an anti-bacterial hydrogel. In this type of hydrogel, Calcium-β glycerophosphate
and NaHCO3 was used as neutralizing and gelling agents. Physiochemical properties
of hydrogel were studied through gelation kinetics. Anti-bacterial activity was
performed against E.coli and S.aureus in which the all compositions Chi.βGP.LA (1),
Chi.βGP.LA (2) and Chi.βGP.LA (1) (4) showed effective anti-bacterial activity.
Effect of LA on different compositions of hydrogels was studied; gelation time was
affected by the different concentrations of lacto-bionic acid, injectability had also an
effect because of varied concentrations of LA. All of the hydrogel compositions were
characterized by FTIR, contact angle measurement and Thermo-gravimetric analysis,
cell studies, degradation studies, swelling studies and SEM.
A novel anti-bacterial hydrogel, having ability to resist E.coli and S.aureus bacteria,
thermo-sensitive as well as injectable has been synthesized. Hydrogel provide an easy
injectable implantation to get rid of surgery. It has non-toxic polymers having no side
effects. It favors a rapid recovery and tissue repair procedure.
