Abstract:
Hydrogels have regenerative behavior therefore they are widely used as injectable
scaffolds in tissue engineering. Chitosan is a well-known biomaterial which is
extensively used in tissue engineering. Chitosan membranes were fabricated in different
compositions by freeze-gelation of mixture of chitosan impregnated with beads of
collagen/alginate. Collagen was used to improve the biocompatibility of scaffolds. FTIR
was used to observe the distribution of constituent materials used in the scaffolds.
Swelling and degradation studies showed good equilibrium ratio in PBS solution. The
mechanical strength of these scaffolds matches with the mechanical strength of natural
tissues. These results showed that collagen/alginate scaffolds could be potential candidate
for tissue engineering. These results encourage the use of chitosan scaffolds and
significance of collagen/alginate scaffolds for regenerating tissues and organs
