Synthesis and Characterization of Carbon & Nitrogen based Covalent Organic Framework to Explore Biomedical Application

Abstract

Covalent organic frameworks (COFs) represent a class of advanced porous materials with outstanding properties such as less density, excellent surface area, and adjustable pore structure and size. These materials proved themselves promising in several fields including separation science, catalysis, sensing, and biomedicine. Recently, many techniques have been developed to synthesize different types of COFs for instance boron-based COFs, imine-based COF, hydrazine-based COFs, and ketoenamine-based COFs according to the nature of linkers and the purpose of application. Among these types of COFs, imine-based COFs are found to be most potential candidate for various applications. Major selection factors in the synthesis of COFs include stability of monomers and facile synthesis route at room temperature. Keeping in view all the above aspects, an imine-based COF has been synthesized at room temperature. Triformylbenzene (TFB) and benzidine (BD) monomers reacted at reported conditions and successfully obtained COF, donated as TFB-BD. Successful synthesis and structure of the COF TFB-BD was confirmed by FTIR and XRD. In FTIR the C=N peak at 1617 cm-1 clearly indicated the formation of framework between the two monomers. In XRD strongest diffraction peak at 2Ө at 2.66° presented confirmation of crystalline nature of synthesized COF-TFB-BD. Furthermore, in SEM and TEM imaging, the morphological characteristic showed porous nature of the prepared COF. Literature describes the utilization of this COF may be explored for biomedical application.